The physiological response to cardiovascular `orphan' G protein-coupled receptor agonists
Article Abstract:
A G protein-coupled receptor has been discovered in the heart and coronary arteries that has the opposite effect as other pressor agents. The receptor binds urotensin-II, and when urotensin-II is given to monkeys, it substantially lowers stroke volume and can even cause myocardial ischemia.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
Article Abstract:
Heat shock protein 70 is capable of binding to monocytes and inducing the production of pro-inflammatory cytokines. It operates through two different mechanisms, one dependent on CD14 and intracellular calcium and one independent of CD14 and dependent on intracellular calcium.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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Nitric oxide modulates HIV-1 replication
Article Abstract:
Nitric oxide appears to inhibit HIV reproduction in cells that have recently been infected and to reactivate the virus in chronically infected cells. Nitric oxide is a naturally occurring substance in the body that relaxes blood vessels.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 1999
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